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The IRLS procedure does not guarantee the variance estimates to be postive nor the co-expression parameters to be bounded. To address this, this function evaluates the percentage of genes with negative variance estimates; sets the their co-expressions to 0 as these genes do not have sufficient biological variations. This function also evaluates the percentage of gene pairs with out-of-bound co-expression estimates; sets the co-expressions greater than 1 to 1; set the co-expressions smaller than -1 to -1.

Usage

post_process_est(est)

Arguments

est

Estimated co-expression matrix from IRLS

Value

Post-processed correlation matrix